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Neuro-Oncology 1999 1(1):52-60; doi:10.1093/neuonc/1.1.52
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© 1999 by the Society forNeuro-Oncology

Morphologic and molecular genetic aspects of oligodendroglialneoplasms

Sandra H. Bigner2, B.K. Ahmed Rasheed, Rodney Wiltshire and Roger E. McLendon

Department of Pathology, Duke University Medical Center, Durham, NC27710

2 Address correspondence and reprint requests to Sandra H. Bigner, MD, DukeUniversity Medical Center, Box 3712, Durham, NC 27710.


  Abstract

Morphologic criteria for diagnosing oligodendrogliomas and for classifyingthem as well-differentiated (World Health Organization grade II) andanaplastic (World Health Organization grade III) are well recognized.Nevertheless, applying these guidelines to specific cases often revealsdiscrepancies among different observers. In addition, whether a given tumoralso contains an astrocytic component may be debatable. Loss of heterozygositystudies have demonstrated that oligodendroglial neoplasms have a highincidence of loss of the 1p and 19q chromosomal arms. Although loss ofheterozygosity for portions of 19q are sometimes seen in astrocytic neoplasms,these tumors seldom show complete loss of 19q accompanied by loss of 1p. Lossof 9p or homozygous deletion of the CDKN2 gene or both are associatedwith anaplastic oligodendrogliomas, whereas loss of 17p or TP53 genemutations or both are frequent in astrocytomas, but rare inoligodendrogliomas. These observations suggest that molecular geneticparameters could provide an objective, reproducible framework for classifyingoligodendroglial neoplasms.

Received September 4, 1998; Accepted October 1, 1998


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