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Neuro-Oncology 1999 1(4):261-267; doi:10.1093/neuonc/1.4.261
© 1999 by Society
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© 1999 by the Society forNeuro-Oncology

Immunohistochemical staining for ganglioside GD1b as a diagnostic andprognostic marker for primary human brain tumors

Theodore C. Comas, Tadashi Tai, David Kimmel, Bernd W. Scheithauer, Peter C. Burger, Dennis K. Pearl, Scott D. Jewell and Allan J. Yates2

The Ohio State University, Columbus, OH 43210 (T.C.C.,D.K.P., S.D.J., A.J.Y.); Tokyo Metropolitan Instituteof Medical Science, Tokyo, Japan (T.T.); MayoFoundation, Rochester, MN 55905 (D.K., B.W.S.); and Johns Hopkins University, Baltimore, MD 21287(P.C.B.)

2 Address correspondence and reprint requests to Allan J. Yates, M.D., Ph.D.,Professor and Head, Division of Neuropathology, Room 4168 Graves Hall, 333West 10th Ave., Columbus, OH 43210.


  Abstract

Immunohistochemical staining intensity for ganglioside GD1b was determinedfor 108 human neuroectodermal tumors. Most of the tissue elements thatimmunostained were tumor cells; only a few axons and occasional neuronsreacted in some specimens. All pilocytic astrocytomas stained very positively,whereas none of the ependymomas and only 11% of primitive neuroectodermaltumors, 20% of glioblastomas, and 28% of anaplastic astrocytomas showed morethan faint staining. A similar association between grade and immunostainingwas seen in tumors containing an oligodendrogliomatous component, butreactivity was not as strong as in astrocytic tumors or primitiveneuroectodermal tumors. Results of Cox regression showed significantassociations between immunostaining intensity and survival for all cases takentogether (P = 0.007); for the group consisting of astrocytomas,oligoastrocytomas, and oligodendrogliomas (P = 0.002); and forastrocytomas alone (P = 0.04). Results were also significant using aproportional hazards model controlling for patient age (all cases P =0.005; astrocytomas only P = 0.02), but not when controlling fortumor grade. Our results indicate that immunohistochemical staining for GD1bis correlated with tumor grade and that it may be of prognostic utility insome primary human brain tumors, especially astrocytomas.

Received November 24, 1998; Accepted June 4, 1999


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