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Neuro-Oncology 2000 2(2):120-124; doi:10.1093/neuonc/2.2.120
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© 2000 by the Society forNeuro-Oncology

Lack of association of rare alleles in the HRAS variable numberof tandem repeats (VNTR) region with adult glioma

Pengchin Chen, John K. Wiencke, Kathleen Conway, Sharon N. Edmiston, Rei Miike and Margaret Wrensch2

Laboratory for Molecular Epidemiology, Department ofEpidemiology and Biostatistics, School of Medicine, University of California,San Francisco, CA 94143-0560 (P.C., J.K.W., R.M., M.W.); and the Molecular Epidemiology Laboratory, Department ofEpidemiology, Lineberger Comprehensive Cancer Center, University of NorthCarolina, Chapel Hill, NC 27599-7400 (K.C., S.N.E.)

2 Address correspondence and reprint requests to Margaret Wrensch, Department ofEpidemiology and Biostatistics, University of California, 44 Page St., Suite503, San Francisco, CA 94143-1215.


  Abstract

HRAS rare alleles have been associated with the increasedsusceptibility to a variety of cancers. In the present study we examined thehypothesis that HRAS rare alleles are a risk factor for adult gliomain a population-based case-control study of adult glioma in six San FranciscoBay Area counties. We compared the prevalence of rare alleles in the variablenumber of tandem repeats region of HRAS in the germline DNA from 73white adults who had gliomas with that of 65 controls. Overall, the prevalenceof rare alleles in cases was not different from the prevalence of those incontrols according to two definitions of rare alleles. We found that 25 of 73(34%) of cases versus 25 of 65 (38%) of controls had at least one allele thatwas not 30, 46, 69, or 87 repeats; 4 of 73 (5%) of cases versus 6 of 65 (9%)of controls carried one or more alleles with 33, 39, 42, 53, 59, 63, 68, 105,or 114 repeats. The proportion of rare alleles was somewhat higher amongsubjects with anaplastic astrocytoma. Among women, cases were less likely thancontrols to have HRAS rare alleles, whereas among men, cases wereslightly more likely to have HRAS rare alleles, but none of theseresults approach statistical significance. Our data do not suggest an excessof HRAS rare alleles among adult glioma cases.

Received September 3, 1999; Accepted January 5, 2000


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