Skip Navigation

Neuro-Oncology 2000 2(3):145-150; doi:10.1093/neuonc/2.3.145
© 2000 by Society
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Raithatha, S. A.
Right arrow Articles by Forsyth, P. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Raithatha, S. A.
Right arrow Articles by Forsyth, P. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2000 by the Society forNeuro-Oncology

Localization of gelatinase-A and gelatinase-B mRNA and protein in humangliomas

Sheetal A. Raithatha, Huong Muzik, N. Barry Rewcastle, Randal N. Johnston, Dylan R. Edwards and Peter A. Forsyth1

Departments of Oncology (S.A.R., H.M.), Clinical Neurosciences (S.A.R., H.M., P.A.F.), Medical Biochemistry (R.N.J.), and Pediatrics (P.A.F.), The University of Calgary, Calgary,Alberta, Canada T2N 4N1; Department of Pathology,Foothills Hospital, Calgary, Alberta, Canada, T2N 2T9 (N.B.R.); School of Biological Sciences, University of East Anglia,Norwich, Norfolk, England NR4 7TJ (D.R.E.); and the Department of Medicine, Tom Baker Cancer Centre, Calgary,Alberta, Canada T2N 4N2 (P.A.F.)

1 Address correspondence and reprint requests to Peter Forsyth, Tom Baker CancerCentre, 1331 29th St. N.W., Calgary, Alberta, Canada.


  Abstract

Malignant gliomas maintain a poor prognosis and survival rate due to theirmarked local invasive growth and neovascularization. Matrix metalloproteinases(MMPs) have been implicated in glioma invasion and angiogenesis, but it isunknown whether they are produced by the tumor cells or surrounding stroma.Using in situ hybridization and immunohistochemistry, we found expression ofmRNA for both gelatinase-A (MMP2) and gelatinase-B (MMP9) localized to tumorcells and vascular structures in glioma sections. Gelatinase-A proteinexpression was detected most prominently in tumor cells, with very littlesignal seen in vasculature. Gelatinase-B protein expression was prominent invascular structures but was also expressed in tumor cells. Our data show thatthese proteases are produced by glioma cells and vascular structures andsuggest that synthetic MMP inhibitors might be useful in this disease.

Received September 9, 1999; Accepted February 2, 2000


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Neuro OncologyHome page
F. Baumann, P. Leukel, A. Doerfelt, C. P. Beier, K. Dettmer, P. J. Oefner, M. Kastenberger, M. Kreutz, T. Nickl-Jockschat, U. Bogdahn, et al.
Lactate promotes glioma migration by TGF-{beta}2-dependent regulation of matrix metalloproteinase-2
Neuro Oncology, August 1, 2009; 11(4): 368 - 380.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. Delamarre, S. Taboubi, S. Mathieu, C. Berenguer, V. Rigot, J.-C. Lissitzky, D. Figarella-Branger, L. Ouafik, and J. Luis
Expression of Integrin {alpha}6{beta}1 Enhances Tumorigenesis in Glioma Cells
Am. J. Pathol., August 1, 2009; 175(2): 844 - 855.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. A. Mayes, Y. Hu, Y. Teng, E. Siegel, X. Wu, K. Panda, F. Tan, W.K. A. Yung, and Y.-H. Zhou
PAX6 Suppresses the Invasiveness of Glioblastoma Cells and the Expression of the Matrix Metalloproteinase-2 Gene.
Cancer Res., October 15, 2006; 66(20): 9809 - 9817.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. J. Brat, A. A. Castellano-Sanchez, S. B. Hunter, M. Pecot, C. Cohen, E. H. Hammond, S. N. Devi, B. Kaur, and E. G. Van Meir
Pseudopalisades in Glioblastoma Are Hypoxic, Express Extracellular Matrix Proteases, and Are Formed by an Actively Migrating Cell Population
Cancer Res., February 1, 2004; 64(3): 920 - 927.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. Choe, J. K. Park, L. Jouben-Steele, T. J. Kremen, L. M. Liau, H. V. Vinters, T. F. Cloughesy, and P. S. Mischel
Active Matrix Metalloproteinase 9 Expression Is Associated with Primary Glioblastoma Subtype
Clin. Cancer Res., September 1, 2002; 8(9): 2894 - 2901.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.