© 2001 by Society
© 2001 by the Society forNeuro-Oncology
Trends in incidence of primary brain tumors in the United States,1985-1994
Division of Epidemiology and Biostatistics, School ofPublic Health, University of Illinois at Chicago, Chicago, IL 60612 (P.J.J.,B.J.M., T.S.S., S.F., F.G.D.); and Central Brain TumorRegistry of the United States, Chicago, IL 60632 (P.J.J., B.J.M., T.S.S.,S.F., F.G.D.)
2 Address correspondence and reprint requests to Bridget J. McCarthy, Divisionof Epidemiology and Biostatistics (M/C 922), School of Public Health,University of Illinois at Chicago, 2121 W. Taylor St., Chicago, IL 60612-7260.
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Abstract |
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Brain tumor incidence has increased over the last 20 years in all agegroups, both overall and for specific histologies. Reasons attributed to theseincreases include increase in lymphoma due to HIV/AIDS, introduction ofcomputed tomography/magnetic resonance imaging, and changes incoding/classification. The purpose of this study was to describe overall andhistologic-specific incidence trends in a population-based series of primarybenign and malignant brain tumors. Data from the Central Brain Tumor Registryof the United States from 1985 through 1994 were used to determine incidencetrends in the broad age groups 0-19, 20-64, and 65 years, both overall and forselected histologies. Poisson regression was used to express trends as averageannual percentage change. Overall, incidence increased modestly (annualpercentage change 0.9%, 95% confidence interval, 0.4, 1.4). When lymphomaswere excluded, this result was not statistically significant (annualpercentage change 0.5%, 95% confidence interval, 0.1, 1.1). Specifichistologies that were increasing were lymphomas in individuals aged 20 to 64years and in males aged 65 years or older, ependymomas in the population aged20 to 64 years, nerve sheath tumors in males, and pituitary tumors in females.Increases that were not specific to any population subgroup were seen forglioblastoma, oligodendrogliomas, and astrocytomas, excluding not otherwisespecified (NOS) tumors. Corresponding decreases were noted for NOS,astrocytoma NOS, and glioma NOS. Increasing incidence trends for lymphomaswere consistent with previous literature. Improvements in diagnostictechnology in addition to changes in classification and coding were likely tobe responsible for decreases seen in incidence of NOS subgroups andcorresponding increases in glioma subgroups. In contrast, the increasesidentified for ependymomas, nerve sheath tumors, and pituitary tumors wereless likely to be artifacts of improvements in diagnosis, and they warrantfurther study.
Received October 5, 2000; Accepted February 16, 2001
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