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Neuro-Oncology 2002 4(3):187-191; doi:10.1093/neuonc/4.3.187
© 2002 by Society
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© 2002 by the Society forNeuro-Oncology

Intravascular lymphomatosis presenting with a conus medullaris syndromemimicking disseminated encephalomyelitis

Stefan Schwarz1, Saida Zoubaa, Michael Knauth, Clemens Sommer and Brigitte Storch-Hagenlocher

Department of Neurology and Neuroradiology (S.S.,M.K., B.S.-H.) and Department of Pathology, Divisionof Neuropathology (S.Z., C.S.), University of Heidelberg, Heidelberg 69120,Germany

1 Address correspondence and reprint requests to Stefan Schwarz, Department ofNeurology, Klinikum Mannheim of the University of Heidelberg,Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.


  Abstract

We describe the clinical, radiologic, and postmortem findings of a42-year-old man with intravascular lymphomatosis. The patient presented with aconus medullaris syndrome followed by progressive, disseminated spinal andcerebral symptoms. Disseminated encephalomyelitis was suspected due to theclinical, radiologic, and cerebrospinal fluid findings and the results of astereotactic brain biopsy, all of which were compatible with inflammatory CNSdisease. Treatment with methylprednisolone and cyclophosphamide led to atemporary remission of symptoms. The patient died 13 months after onset ofsymptoms. The diagnosis of disseminated intravascular lymphomatosis wasestablished after death.

Received October 11, 2001; Accepted January 14, 2002


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