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Neuro-Oncology 2003 5(3):214-216; doi:10.1215/S1152851702000467
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© 2003 by the Society forNeuro-Oncology

Paraneoplastic limbic encephalitis and possible narcolepsy in a patientwith testicular cancer: Case study

Joseph C. Landolfi1 and Mangala Nadkarni

New Jersey Neuroscience Institute—JFK Medical Center, Edison,NJ 08818, and Seton Hall University School of Graduate Medical Education,South Orange, NJ 07079, USA

1 Address correspondence to Joseph C. Landolfi, Assistant Professor ofNeurology, New Jersey Neuroscience Institute—JFK Medical Center, 65James Street, Edison, NJ 08818, USA(jlandolfi{at}solarishs.org).


  Abstract

We describe a patient who presented with a clinical syndrome of limbicencephalitis, narcolepsy, and cataplexy. The anti-Ma2 antibody was positive.Although there was no mass on imaging, orchiectomy was performed in thispatient, and testicular carcinoma was found. This is the first known case oflimbic encephalitis and anti-Ma2 antibody to be associated with cataplexy andpossible narcolepsy. Neurological symptoms precede the diagnosis of cancer in50% of patients with paraneoplastic syndromes, and clinicians are thereforestrongly advised to evaluate patients with neurological symptoms for thiscondition.

Received November 6, 2002; Accepted January 16, 2003


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