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Neuro-Oncology 2003 5(3):217-220; doi:10.1215/S115285170200042X
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© 2003 by the Society forNeuro-Oncology

Unusual presentation of adult metastatic peritoneal medulloblastomaassociated with a ventriculoperitoneal shunt: A case study and review of theliterature

Paul M. Magtibay1, Jonathan A. Friedman, Ravi D. Rao, Jan C. Buckner and William A. Cliby

Divisions of Gynecologic Oncology (P.M.M.,W.A.C.), Neurologic Surgery (J.A.F.), and Medical Oncology (R.D.R, J.C.B.), Mayo Clinic Rochester,Mayo Foundation, Rochester, MN 55905, USA

1 Address correspondence to Paul M. Magtibay, Division of Gynecologic Oncology,Department of Obstetrics/Gynecology, Mayo Graduate School of Medicine, MayoClinic, Rochester, MN 55905, USA(magtibay.paul{at}mayo.edu).


  Abstract

Patients with medulloblastoma uncommonly develop extracerebral metastases.We describe an adult patient with the unusual occurrence of intraperitonealmetastases associated with a ventriculoperitoneal (VP) shunt, as well as hersubsequent treatment with high-dose chemotherapy and bone marrowtransplantation. We review the literature regarding this rare presentation andassociation of metastatic spread via VP shunt devices. A 37-year-old womanpresented with a rapidly enlarging pelvic mass. She had a history ofmedulloblastoma and had been treated with a combination of surgery,chemotherapy, and radiation 5 years previously, at which time a VP shunt hadbeen placed for cerebrospinal fluid leakage. At laparotomy, she hadunresectable intraperitoneal metastatic medulloblastoma. After an excellentresponse to cyclophosphamide, etoposide, and cisplatin, she underwent aresection of residual disease, followed by high-dose chemotherapy and a bonemarrow transplant. We conclude that adult onset medulloblastoma withmetastasis to the peritoneal cavity is rare and may be associated with a VPshunt.

Received October 30, 2002; Accepted March 19, 2003


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