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Neuro-Oncology 2003 5(4):255-260; doi:10.1215/S1152851703000012
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© 2003 by the Society forNeuro-Oncology

Does brain tumor histology influence cognitive function?

Anne E. Kayl1 and Christina A. Meyers

The University of Texas M.D. Anderson Cancer Center, Department ofNeuro-Oncology, Houston, TX 77030

1 Address correspondence to Anne E. Kayl, University of Texas M.D. AndersonCancer Center, Department of Neuro-Oncology (431), 1515 Holcombe Blvd.,Houston, TX 77030(akayl{at}mail.mdanderson.org).


  Abstract

This retrospective study investigated the relationship between tumorhistology and postsurgical cognitive function in patients diagnosed withmalignant brain tumors. The neuropsychological functioning of 24 adultpatients diagnosed with glioblastoma multiforme (GBM) was compared with theneuropsychological functioning of 24 adult patients diagnosed with anaplasticastrocytoma (AA). The groups were matched with respect to patient age, gender,and education, as well as tumor location and tumor volume. The mean raw testscores of the AA patient group were superior to the mean scores of the GBMpatient group on nearly all measures administered. However, significantperformance differences were not detected for any of 5 neuropsychologicaldomain scores (Intellectual, Language, Memory, Executive, and Motor Function).Analysis of covariance (ANCOVA) revealed that tumor histology was not asignificant predictor of domain score after controlling for tumor volume.Multiple regression and correlation analyses supported the results of theANCOVA by offering further evidence of weak relationships between tumor type,tumor volume, and neuropsychological test scores. We conclude that tumorhistology is not clearly predictive of cognitive performance in adults with AAand GBM.

Received January 9, 2003; Accepted April 30, 2003


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