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Neuro-Oncology 2004 6(4):274-280; doi:10.1215/S1152851704000109
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© 2004 by the Society forNeuro-Oncology

Meningioma and schwannoma risk in adults in relation to family history ofcancer

Deirdre A. Hill1, Martha S. Linet, Peter M. Black, Howard A. Fine, Robert G. Selker, William R. Shapiro and Peter D. Inskip

Division of Cancer Epidemiology and Genetics (D.A.H.,M.S.L., P.D.I.) and Neuro-Oncology Branch (H.A.F.),National Cancer Institute, National Institutes of Health, Department of Healthand Human Services, Bethesda, MD 20892; Department ofNeurosurgery, Brigham and Women's Hospital, Boston, MA 02115 (P.M.B.); Division of Neurosurgery, Western Pennsylvania Hospital,Pittsburgh, PA 15224 (R.G.S.); and Department ofNeurology, Barrow Neurological Institute, St. Joseph's Hospital and MedicalCenter, Phoenix, AZ 85013 (W.R.S.); USA

1 Address correspondence to Deirdre A. Hill, Division of Cancer Epidemiology andGenetics, National Cancer Institute, 6120 Executive Boulevard, MSC 7238 N,Bethesda, MD 20892-7238(dhill{at}mail.nih.gov).


  Abstract

Relatively little is known about factors that contribute to the developmentof meningioma and vestibular schwannoma, two intracranial nervous systemtumors. We evaluated the risk of these tumors in relation to family history ofmalignant or benign tumors. Incident cases of meningioma (n = 197) orschwannoma (n = 96) were identified at three U.S. referral hospitals betweenJune 1994 and August 1998. Controls (n = 799) admitted to the same hospitalsfor nonmalignant conditions were matched to cases on age, sex, race/ethnicity,hospital, and proximity of residence to hospital. We found that risk ofmeningioma was increased among persons reporting a family history of a benignbrain tumor (odds ratio [OR], 4.5; 95% confidence interval [CI],1.0–21.0; n = 5) or melanoma (OR, 4.2; 95% CI, 1.2–15.0; n = 5). Afamily history of breast cancer was associated with an elevated meningiomarisk among participants aged 18 to 49 years (OR, 3.9; 95% CI, 1.4–11.0;n = 8) but a reduced risk among older respondents (OR, 0.2; 95% CI,0.1–0.7; n = 3). Family history of cancer did not differ betweenschwannoma cases and controls, although the statistical power to detectassociations was limited. Some relative risk estimates were based on a smallnumber of observations and may have arisen by chance. Inheritance ofpredisposing genes, shared environmental factors, or both within families witha history of benign brain tumors, melanoma, or possibly breast cancer may berelated to altered meningioma risk.

Received January 30, 2004; Accepted April 26, 2004


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