© 2004 by Society
© 2004 by the Society forNeuro-Oncology
Diagnostic and prognostic significance of genetic regional heterogeneityin meningiomas
Neuro-Oncology Research (W.K.P., N.C.H., W.P.H., J.P.,A.C.S.), Neurosurgery Research Laboratory (W.K.P.,M.C.P., A.C.S.), and Division of Neuropathology(S.W.C.), Barrow Neurological Institute of St. Joseph's Hospital and MedicalCenter, Phoenix, AZ 85013, USA
2 Address correspondence to Adrienne C. Scheck, Neuro-Oncology Research, BarrowNeurological Institute of St. Joseph's Hospital and Medical Center, 350 WestThomas Road, Phoenix, AZ 85013, USA(ascheck{at}chw.edu).
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Abstract |
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We analyzed the frequency and regional distribution of cells with geneticabnormalities of chromosomes 1, 14, and 22 in meningiomas. This data wasevaluated for correlation to the clinical outcome of the patients. Eightdefined areas of each of 77 paraffin-embedded meningioma samples (59 grade I,13 grade II, and 5 grade III) were analyzed by fluorescent in situhybridization using bacterial artificial chromosome probes localized tochromosomes 1p36.32, 1q25.3, 14q13.3, 14q32.12, 22q11.2, and 22q12.1-3.Chromosome deletion was considered to be regionally heterogeneous if <7regions showed cells with chromosome deletions. Deletion of 1p occurred in 35%of the grade I tumors. Distribution of cells with 1p deletion was regionallyheterogeneous in 25% and homogeneous in 10% of grade I tumors. Distribution ofcells with deletion of 1p was regionally heterogeneous in 23% and homogeneousin 69% of the grade II tumors. All grade III meningiomas had homogeneousdistribution of cells with deletion of chromosome 1p. Distribution of cellswith deletion of 14q was regionally heterogeneous in 27% and homogeneous in 2%of the grade I meningiomas, heterogeneous in 31% and homogeneous in 62% of thegrade II tumors, and heterogeneous in 40% and homogeneous in 60% of the gradeIII meningiomas. Distribution of cells with deletion of 22q was regionallyheterogeneous in 15% and homogeneous in 3% of the grade I tumors,heterogeneous in 15% and homogeneous in 31% of grade II tumors, andhomogeneous in 20% of the grade III meningiomas. Distribution of cells withtrisomy 22q was regionally heterogeneous in 10% of grade I tumors,heterogeneous in 23% of grade II, and homogeneous in 80% of grade IIImeningiomas. The proportion of patients with a deletion of 22q (eitherhomogeneous or heterogeneous) who had recurrence was greater than theproportion of those without 22q deletion who had recurrence, and deletion of22q was significantly associated with radiologically detected recurrence(P < 0.05). We conclude that the appearance of chromosomalaberrations in different areas of the tumor demonstrates the importance ofregional heterogeneity in the biological behavior of meningiomas.
Received February 17, 2004; Accepted May 17, 2004
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