© 2005 by the Society for Neuro-Oncology
The role of pericytes in blood-vessel formation and maintenance
Department of Neurological Surgery, Brain Tumor Research Center and UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
2 Address correspondence to Gabriele Bergers, University of California San Francisco, Department of Neurological Surgery, 513 Parnassus Avenue, San Francisco, CA 94143, USA (bergers{at}itsa.ucsf.edu).
 |
Abstract |
|---|
Blood vessels are composed of two interacting cell types. Endothelial cells form the inner lining of the vessel wall, and perivascular cells—referred to as pericytes, vascular smooth muscle cells or mural cells—envelop the surface of the vascular tube. Over the last decades, studies of blood vessels have concentrated mainly on the endothelial cell component, especially when the first angiogenic factors were discovered, while the interest in pericytes has lagged behind. Pericytes are, however, functionally significant; when vessels lose pericytes, they become hemorrhagic and hyperdilated, which leads to conditions such as edema, diabetic retinopathy, and even embryonic lethality. Recently, pericytes have gained new attention as functional and critical contributors to tumor angiogenesis and therefore as potential new targets for antiangiogenic therapies. Pericytes are complex. Their ontogeny is not completely understood, and they perform various functions throughout the body. This review article describes the current knowledge about the nature of pericytes and their functions during vessel growth, vessel maintenance, and pathological angiogenesis.
Received March 4, 2005; Accepted April 27, 2005
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  N. Minhas, M. Xue, K. Fukudome, and C. J. Jackson Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function FASEB J, March 1, 2010; 24(3): 873 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Juchem, D. R. Weiss, B. Gansera, B. M. Kemkes, J. Mueller-Hoecker, and S. Nees Pericytes in the macrovascular intima: possible physiological and pathogenetic impact Am J Physiol Heart Circ Physiol, March 1, 2010; 298(3): H754 - H770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-C. Yao, P. Baluk, J. Feng, and D. M. McDonald Steroid-Resistant Lymphatic Remodeling in Chronically Inflamed Mouse Airways Am. J. Pathol., March 1, 2010; 176(3): 1525 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Yu, B. Su, M. Hollomon, Y. Deng, V. Facchinetti, and E. S. Kleinerman Vasculogenesis Driven by Bone Marrow-Derived Cells Is Essential for Growth of Ewing's Sarcomas Cancer Res., February 15, 2010; 70(4): 1334 - 1343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Schadler, P. A. Zweidler-McKay, H. Guan, and E. S. Kleinerman Delta-Like Ligand 4 Plays a Critical Role in Pericyte/Vascular Smooth Muscle Cell Formation during Vasculogenesis and Tumor Vessel Expansion in Ewing's Sarcoma Clin. Cancer Res., February 1, 2010; 16(3): 848 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J Woad, A. J Hammond, M. Hunter, G. E Mann, M. G Hunter, and R. S Robinson FGF2 is crucial for the development of bovine luteal endothelial networks in vitro Reproduction, September 1, 2009; 138(3): 581 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. Stratman, W. B. Saunders, A. Sacharidou, W. Koh, K. E. Fisher, D. C. Zawieja, M. J. Davis, and G. E. Davis Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices Blood, July 9, 2009; 114(2): 237 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. McFarland, J. Stewart Jr., A. Hamza, R. Nordal, D. J. Davidson, J. Henkin, and C. L. Gladson Plasminogen Kringle 5 Induces Apoptosis of Brain Microvessel Endothelial Cells: Sensitization by Radiation and Requirement for GRP78 and LRP1 Cancer Res., July 1, 2009; 69(13): 5537 - 5545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Sennino, F. Kuhnert, S. P. Tabruyn, M. R. Mancuso, D. D. Hu-Lowe, C. J. Kuo, and D. M. McDonald Cellular Source and Amount of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor in Tumors Determine Response to Angiogenesis Inhibitors Cancer Res., May 15, 2009; 69(10): 4527 - 4536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Shi Cochlear Pericyte Responses to Acoustic Trauma and the Involvement of Hypoxia-Inducible Factor-1{alpha} and Vascular Endothelial Growth Factor Am. J. Pathol., May 1, 2009; 174(5): 1692 - 1704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Odaka Localization of Mesenchymal Cells in Adult Mouse Thymus: Their Abnormal Distribution in Mice With Disorganization of Thymic Medullary Epithelium J. Histochem. Cytochem., April 1, 2009; 57(4): 373 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Solomon, K. Pelton, K. Boucher, J. Joo, C. Tully, D. Zurakowski, C. P. Schaffner, J. Kim, and M. R. Freeman Ezetimibe Is an Inhibitor of Tumor Angiogenesis Am. J. Pathol., March 1, 2009; 174(3): 1017 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Manzur, J. Hamzah, and R. Ganss Modulation of G Protein Signaling Normalizes Tumor Vessels Cancer Res., January 15, 2009; 69(2): 396 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Komita, X. Zhao, J. L. Taylor, L. J. Sparvero, A. A. Amoscato, S. Alber, S. C. Watkins, A. D. Pardee, A. K. Wesa, and W. J. Storkus CD8+ T-Cell Responses against Hemoglobin-{beta} Prevent Solid Tumor Growth Cancer Res., October 1, 2008; 68(19): 8076 - 8084. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Pfister, Y. Feng, F. vom Hagen, S. Hoffmann, G. Molema, J.-L. Hillebrands, M. Shani, U. Deutsch, and H.-P. Hammes Pericyte Migration: A Novel Mechanism of Pericyte Loss in Experimental Diabetic Retinopathy Diabetes, September 1, 2008; 57(9): 2495 - 2502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Hilberg, G. J. Roth, M. Krssak, S. Kautschitsch, W. Sommergruber, U. Tontsch-Grunt, P. Garin-Chesa, G. Bader, A. Zoephel, J. Quant, et al. BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy Cancer Res., June 15, 2008; 68(12): 4774 - 4782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Du, C. Petritsch, K. Lu, P. Liu, A. Haller, R. Ganss, H. Song, S. Vandenberg, and G. Bergers Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM Neuro Oncology, June 1, 2008; 10(3): 254 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-C. Gerard, S. Poncin, B. Caetano, P. Sonveaux, J.-N. Audinot, O. Feron, I. M. Colin, and F. Soncin Iodine Deficiency Induces a Thyroid Stimulating Hormone-Independent Early Phase of Microvascular Reshaping in the Thyroid Am. J. Pathol., March 1, 2008; 172(3): 748 - 760. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Tigges, E. G. Hyer, J. Scharf, and W. B. Stallcup FGF2-dependent neovascularization of subcutaneous Matrigel plugs is initiated by bone marrow-derived pericytes and macrophages Development, February 1, 2008; 135(3): 523 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Kutcher, A. Y. Kolyada, H. K. Surks, and I. M. Herman Pericyte Rho GTPase Mediates Both Pericyte Contractile Phenotype and Capillary Endothelial Growth State Am. J. Pathol., August 1, 2007; 171(2): 693 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Hall Review of the Pericyte during Angiogenesis and its Role in Cancer and Diabetic Retinopathy Toxicol Pathol, October 1, 2006; 34(6): 763 - 775. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lamagna and G. Bergers The bone marrow constitutes a reservoir of pericyte progenitors J. Leukoc. Biol., October 1, 2006; 80(4): 677 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A Vonnahme, D. A Redmer, E. Borowczyk, J. J Bilski, J. S Luther, M. L. Johnson, L. P Reynolds, and A. T Grazul-Bilska Vascular composition, apoptosis, and expression of angiogenic factors in the corpus luteum during prostaglandin F2{alpha}-induced regression in sheep. Reproduction, June 1, 2006; 131(6): 1115 - 1126. [Abstract] [Full Text] [PDF]
|
|