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Neuro-Oncology 2007 9(3):319-325; doi:10.1215/15228517-2007-016
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Society for Neuro-Oncology

Incidence of gliomas by anatomic location

Suvi Larjavaara, Riitta Mäntylä, Tiina Salminen, Hannu Haapasalo, Jani Raitanen, Juha Jääskeläinen and Anssi Auvinen

Tampere School of Public Health, University of Tampere, Tampere 33520 (S.L., T.S., J.R., A.A.); Department of Radiology, Helsinki University Central Hospital, Helsinki 00290 (R.M.); Department of Pathology, Tampere University Hospital, Tampere 33520 (H.H.); Department of Neurosurgery, Kuopio University Hospital, Kuopio 70211 (J.J.); and STUK—Radiation and Nuclear Safety Authority, Helsinki 00881 (A.A.); Finland

Address correspondence to Suvi Larjavaara, School of Public Health, University of Tampere, FIN-33016 Tampere, Finland (suvi.larjavaara{at}uta.fi).


  Abstract

The anatomic location of a glioma influences prognosis and treatment options. The aim of our study was to describe the distribution of gliomas in different anatomic areas of the brain. A representative population-based sample of 331 adults with glioma was used for preliminary analyses. The anatomic locations for 89 patients from a single center were analyzed in more detail from radiologic imaging and recorded on a three-dimensional 1 x 1 x 1-cm grid. The age-standardized incidence rate of gliomas was 4.7 per 100,000 person-years. The most frequent subtypes were glioblastoma (47%) and grade II-III astrocytoma (23%), followed by oligodendroglioma and mixed glioma. The gliomas were located in the frontal lobe in 40% of the cases, temporal in 29%, parietal in 14%, and occipital lobe in 3%, with 14% in the deeper structures. The difference in distribution between lobes remained after adjustment for their tissue volume: the tumor:volume ratio was 4.5 for frontal, 4.8 for temporal, and 2.3 for parietal relative to the occipital lobe. The area with the densest occurrence was the anterior subcortical brain. Statistically significant spatial clustering was found in the three-dimensional analysis. No differences in location were found among glioblastoma, diffuse astrocytoma, and oligodendroglioma. Our results demonstrate considerable heterogeneity in the anatomic distribution of gliomas within the brain.

Keywords: brain neoplasms, diagnostic imaging, glioma, incidence

Received November 1, 2005; Accepted November 13, 2006


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