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Neuro-Oncology Advance Access published online on October 15, 2009
Neuro-Oncology, doi:10.1093/neuonc/nop002
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© The Author(s) 2009. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

Chromosome 9p and 10q losses predict unfavorable outcome in low-grade gliomas

Caroline Houillier, Karima Mokhtari, Catherine Carpentier, Emmanuelle Crinière, Yannick Marie, Audrey Rousseau, Gentian Kaloshi, Caroline Dehais, Julien Laffaire, Florence Laigle-Donadey, Khê Hoang-Xuan, Marc Sanson and Jean-Yves Delattre

Service de Neurologie 2 – Mazarin, Groupe Hospitalier Pitié-Salpêtrière (AP-HP) (C.H., G.K., C.D., F.L.-D, K.H.-X, M.S., J.-Y.D.); INSERM U975, Université Pierre et Marie Curie Paris VI, Faculté de Médecine Pitié-Salpêtrière, CNRS UMR 7225 and UMR-S975 (K.M., C.C., E.C., Y.M., A.R., J.L., F.L.-D., K.H.-X, M.S., J.-Y.D.); Laboratoire de Neuropathologie R. Escourolle, Groupe Hospitalier Pitié-Salpêtrière (AP-HP) (K.M., A.R.); Paris Cedex, France

Corresponding Author: Caroline Houillier, Service de Neurologie 2 – Mazarin, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France (carolinehouillier{at}yahoo.fr).


  Abstract

The loss of chromosomes 1p–19q is the only prognostic molecular alteration identified in low-grade gliomas (LGGs) to date. Search for loss of heterozygosity (LOH) on chromosomes 1p, 9p, 10q, and 19q was performed in a series of 231 LGGs. Loss of chromosomes 1p–19q was strongly correlated with prolonged progression-free survival (PFS) and overall survival (OS) in univariate and multivariate analyses. LOH on 9p and 10q were associated with shortened PFS (P = .01 and .03, respectively) on univariate analysis. On multivariate analysis, LOH on 9p remained significant for PFS (P = .05), whereas LOH on 10q had a significant effect on OS (P = .02). Search for LOH 9p and 10q appears to be a useful complement to analysis of chromosomes 1p–19q in LGGs.

Keywords: chromosomes 9p and 10q, low-grade gliomas, prognosis

Received January 9, 2009; Accepted May 11, 2009


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