© 2004 by Society
© 2004 by the Society forNeuro-Oncology
Poliovirus receptor CD155-targeted oncolysis of glioma
Departments of Molecular Genetics and Microbiology(M.K.M., M.G.), Surgery (J.H.S.), and Pathology (C.J.W., D.D.B.), Duke University Medical Center,Durham, NC 27710, USA; and Institute of Immunology,Hanover Medical University, 30625 Hanover, Germany (G.B.)
2 Address correspondence to Matthias Gromeier, Department of Molecular Geneticsand Microbiology, Duke University Medical Center, Box 3020, Durham, NC 27710(grome001{at}mc.duke.edu).
Cell adhesion molecules of the immunoglobulin superfamily are aberrantlyexpressed in malignant glioma. Amongst these, the human poliovirus receptorCD155 provides a molecular target for therapeutic intervention with oncolyticpoliovirus recombinants. Poliovirus has been genetically modified throughinsertion of regulatory sequences derived from human rhinovirus type 2 toselectively replicate within and destroy cancerous cells. Efficaciousoncolysis mediated by poliovirus derivatives depends on the presence of CD155in targeted tumors. To prepare oncolytic polioviruses for clinicalapplication, we have developed a series of assays in high-grade malignantglioma (HGL) to characterize CD155 expression levels and susceptibility tooncolytic poliovirus recombinants. Analysis of 6 HGL cases indicates thatCD155 is expressed in these tumors and in primary cell lines derived fromthese tumors. Upregulation of the molecular target CD155 rendered explantcultures of all studied tumors highly susceptible to a prototype oncolyticpoliovirus recombinant. Our observations support the clinical application ofsuch agents against HGL.
Received October 15, 2003; Accepted January 7, 2004
References
-
Asaoka, K., Tada, M., Sawamura, Y., Ikeda, J., and Abe, H.(2000) Dependence of efficient adenoviral gene delivery inmalignant glioma cells on the expression levels of the Coxsackievirus andadenovirus receptor. J. Neurosurg.92,1002-1008.[Web of Science][Medline]
Banker, G., and Goslin, K., Eds. (1998)Culturing Nerve Cells. Cambridge, Mass.: MITpress.
Baury, B., Geraghty, R.J., Masson, D., Lustenberger, P., Spear,P.G., and Denis, M.G. (2001) Organization of the rat Tage4 geneand herpesvirus entry activity of the encoded protein.Gene 265,185-194.[CrossRef][Web of Science][Medline]
Bergelson, J.M., Cunningham, J.A., Droguett, G., Kurt-Jones, E.A.,Krithivas, A., Hong, J.S., Horwitz, M.S., Crowell, R.L., and Finberg, R.W.(1997) Isolation of a common receptor for Coxsackie B viruses andadenoviruses 2 and 5. Science275,1320-1323.
Bernhardt, G., Bibb, J.A., Bradley, J., and Wimmer, E.(1994) Molecular characterization of the cellular receptor forpoliovirus. Virology199,105-113.[CrossRef][Web of Science][Medline]
Bigner S.H., Humphrey, P.A., Wong, A.J., Vogelstein, B., Mark, J.,Friedman, H.S., and Bigner, D.D. (1990) Characterization of theepidermal growth factor receptor in human glioma cell lines and xenografts.Cancer Res. 50,8017-8022.
Bischoff, J.R., Kirn, D.H., Williams, A., Heise, C., Horn, S.,Muna, M., Ng, L., Nye, J.A., Sampson-Johannes, A., Fattaey, A., and McCormick,F. (1996) An adenovirus mutant that replicates selectively inp53-deficient human tumor cells. Science274,373-376.
Coffey, M.C., Strong, J.E., Forsyth, P.A., and Lee, P.W.(1998) Reovirus therapy of tumors with activated Ras pathway.Science 282,1332-1334.
Curiel, D.T. (1999) Strategies to adapt adenoviralvectors for targeted delivery. Ann. N.Y. Acad. Sci.886,158-171.[CrossRef][Web of Science][Medline]
Denis, M.G. (1998) Characterization, cloning andexpression of the Tage4 gene, a member of the immunoglobulin superfamily.Int. J. Oncol. 12,997-1005.[Web of Science][Medline]
DePace, N. (1912) Sulla scomparsa di un enorme cancrovegetante del collo dell'utero senza cura chirurgica.Ginecologia 9,82-89.
Douglas, J.T., Kim, M., Sumerel, L.A., Carey, D.E., and Curiel,D.T. (2001) Efficient oncolysis by a replicating adenovirus (ad)in vivo is critically dependent on tumor expression of primary ad receptors.Cancer Res. 61,813-817.
Dufresne, A.T., Dobrikova, E.Y., Schmidt, S., and Gromeier, M.(2002) Genetically stable picornavirus expression vectors withrecombinant internal ribosomal entry sites. J. Virol.76,8966-8972.
Gladson, C.L., Wilcox, J.N., Sanders, L., Gillespie, G.Y., andCheresh, D.A. (1995) Cerebral microenvironment influencesexpression of the vitronectin gene in astrocytic tumors. J. CellSci. 108,947-956.[Abstract]
Goldbrunner, R.H., Bernstein, J.J., and Tonn, J.C.(1999) Cell-extracellular matrix interaction in glioma invasion.Acta Neurochir. 141,295-305.[CrossRef][Medline]
Goodrich, L.V., Milenkovic, L., Higgins, K.M., and Scott, M.P.(1997) Altered neural cell fates and medulloblastoma in mousepatched mutants. Science277,1109-1113.
Gromeier, M. (2001). Viruses as therapeutic agentsagainst malignant disease of the central nervous system. J. Natl.Cancer Inst. 93,889-890.
Gromeier, M. (2002) Viruses for treating cancer.ASM News 68,438-445.[Web of Science]
Gromeier, M., and Wimmer, E. (2001) Viruses for thetreatment of malignant glioma. Curr. Opin. Mol. Ther.3, 503-508.[Web of Science][Medline]
Gromeier, M., Alexander, L., and Wimmer, E. (1996)Internal ribosomal entry site substitution eliminates neurovirulence inintergeneric poliovirus recombinants. Proc. Natl. Acad. Sci.USA 93,2370-2375.
Gromeier, M., Bossert, B., Arita, M., Nomoto, A., and Wimmer, E.(1999) Dual stem loops within the poliovirus internal ribosomalentry site control neurovirulence. J. Virol.73,958-964.
Gromeier, M., Solecki, D., Patel, D.D., and Wimmer, E.(2000a) Expression of the human poliovirus receptor/CD155 geneduring embryonic development of the central nervous system: Implications forthe pathogenesis of poliomyelitis. Virology273,248-257.[CrossRef][Web of Science][Medline]
Gromeier, M., Lachmann, S., Rosenfeld, M.R., Gutin, P.H., andWimmer, E. (2000b) Intergeneric poliovirus recombinants for thetreatment of malignant glioma. Proc. Natl. Acad. Sci.USA 97,6803-6808.
Harlow, E., and Lane, D. (1988) Antibodies:A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring HarborLaboratory Press.
Izumoto, S., Ohnishi, T., Arita, N., Hiraga, S., Taki, T., andHayakawa, T. (1996) Gene expression of neural cell adhesionmolecule L1 in malignant gliomas and biological significance of L1 in gliomainvasion. Cancer Res.56,1440-1444.
Kinzler, K.W., Bigner, S.H., Bigner, D.D., Trent, J.M., Law, M.L.,O'Brien, S.J., Wong, A.J., and Vogelstein, B. (1987)Identification of an amplified, highly expressed gene in a human glioma.Science 236,70-73.
Koike, S., Taya, C., Kurata, T., Abe, S., Ise, I., Yonekawa, H.,and Nomoto, A. (1991) Transgenic mice susceptible to poliovirus.Proc. Natl. Acad. Sci. USA88,951-955.
Lange, R., Peng, X., Wimmer, E., Lipp, M., and Bernhardt, G.(2001) The poliovirus receptor CD155 mediates cell-to-matrixcontacts by specifically binding to vitronectin.Virology 285,218-227.[CrossRef][Web of Science][Medline]
Li, D., Duan, L., Freimuth, P., and O'Malley, B.W., Jr.(1999) Variability of adenovirus receptor density influences genetransfer efficiency and therapeutic response in head and neck cancer.Clin. Cancer Res. 5,4175-4181.
Li, Y., Pong, R.C., Bergelson, J.M., Hall, M.C., Sagalowsky, A.I.,Tseng, C.P., Wang, Z., and Hsieh, J.T. (1999) Loss of adenoviralreceptor expression in human bladder cancer cells: A potential impact on theefficacy of gene therapy. Cancer Res.59,325-330.
Martuza, R.L., Malick, A., Markert, J.M., Ruffner, K.L., and Coen,D.M. (1991) Experimental therapy of human glioma by means of agenetically engineered virus mutant. Science252,854-856.
Masson, D., Jarry, A., Baury, B., Blanchardie, P., Laboisse, C.,Lustenberger, P., and Denis, M.G. (2001) Overexpression of theCD155 gene in human colorectal carcinoma. Gut49,236-240.
Mendelsohn, C.L., Wimmer, E., and Racaniello, V.R.(1989) Cellular receptor for poliovirus: Molecular cloning,nucleotide sequence, and expression of a new member of the immunoglobulinsuperfamily. Cell 56,855-865.[CrossRef][Web of Science][Medline]
Nobis, P., Zibirre, R., Meyer, G., Kuhne, J., Warnecke, G., andKoch, G. (1985) Production of a monoclonal antibody against anepitope on HeLa cells that is the functional poliovirus binding site.J. Gen. Virol. 66,2563-2569.
Ochiai, H., Moore, S.A., Archer, G.E., Okamura, T., Chewning, T.A.,Marks, J.R., Sampson J.H., and Gromeier, M. (2004) Treatment ofintracerebral neoplasia and neoplastic meningitis with regional delivery ofoncolytic recombinant poliovirus. Clin. Cancer Res. Inpress.
Ren, R.B., Constantini, F., Gorgacz, E.J., Lee, J.J., andRacaniello, V.R. (1990) Transgenic mice expressing a humanpoliovirus receptor: A new model for poliomyelitis.Cell 63,353-362.[CrossRef][Web of Science][Medline]
Rickman, D.S., Tyagi, R., Zhu, X.X., Bobek, M.P., Song, S.,Blaivas, M., Misek, D.E., Israel, M.A., Kurnit, D.M., Ross, D.A., Kish, P.E.,and Hanash, S.M. (2001) The gene for the axonal cell adhesionmolecule TAX-1 is amplified and aberrantly expressed in malignant glioma.Cancer Res. 61,2162-2168.
Sasaki, H., Yoshida, K., Ikeda, E., Asou, H., Inaba, M., Otani, M.,and Kawase, T. (1998) Expression of the neural cell adhesionmolecule in astrocytic tumors: An inverse correlation with malignancy.Cancer 82,1921-1931.[CrossRef][Web of Science][Medline]
Sehgal, A., Boynton, A.L., Young, R.F., Vermeulen, S.S., Yonemura,K.S., Koehler, E.P., Aldape, H.C., Simrell, C.R., and Murphy, G.P.(1998) Cell adhesion molecule Nr-CAM is over-expressed in humanbrain tumors. Int. J. Cancer76,451-458.[CrossRef][Web of Science][Medline]
Shaw, G., Morse, S., Ararat, M., and Graham, F.L.(2002) Preferential transformation of human neuronal cells byhuman adenoviruses and the origin of HEK 293 cells. FASEBJ. 16,869-871.
Sincovics, J.G., and Horvath, J. (1993) Newdevelopments in the virus therapy of cancer: A historical review.Intervirology 36,193-214.[Web of Science][Medline]
Solecki, D.J., Wimmer, E., Lipp, M., and Bernhardt, G.(1999) Identification and characterization of thecis-acting elements of the human CD155 gene core promoter.J. Biol. Chem. 274,1791-1800.
Solecki, D.J., Bernhardt, G., Lipp, M., and Wimmer, E.(2000) Identification of a nuclear respiratory factor-1 bindingsite within the core promoter of the human polio virus receptor/CD155 gene.J. Biol. Chem. 275,12453-12462.
Solecki, D.J., Gromeier, M., Bernhardt, G., and Wimmer, E.(2002) Expression of the human poliovirus receptor/CD155gene is activated by sonic hedgehog. J. Biol. Chem.277,25697-25702.
Stojdl, D.F., Litchy, B., Knowles, S., Marius, R., Atkins, H.,Sonenberg, N., and Bell, J.C. (2000) Exploiting tumor-specificdefects in the interferon pathway with a previously unknown oncolytic virus.Nat. Med. 6,821-825.[CrossRef][Web of Science][Medline]
Tomko, R.P., Xu, R., and Philipson, L. (1997) HCAR andMCAR: The human and mouse cellular receptors for subgroup C adenoviruses andgroup B coxsackieviruses. Proc. Natl. Acad. Sci. USA94,3352-3356.
Uhm, J.H., Dooley, N.P., Kyritsis, A.P., Rao, J.S., and Gladson,C.L. (1999) Vitronectin, a glioma-derived extracellular matrixprotein, protects tumor cells from apoptotic death. Clin. CancerRes. 5,1587-1594.
Zülch, K.J. (1979) Histological Typingof Tumours of the Central Nervous System (InternationalHistological Classification of Tumours, no. 21).Geneva: World Health Organization, pp.19-20.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. A. Campbell, M. Mulvey, I. Mohr, and M. Gromeier Attenuation of Herpes Simplex Virus Neurovirulence with Picornavirus cis-Acting Genetic Elements J. Virol., January 15, 2007; 81(2): 791 - 799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Merrill, E. Y. Dobrikova, and M. Gromeier Cell-Type-Specific Repression of Internal Ribosome Entry Site Activity by Double-Stranded RNA-Binding Protein 76 J. Virol., April 1, 2006; 80(7): 3147 - 3156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ochiai, S. A. Campbell, G. E. Archer, T. A. Chewning, E. Dragunsky, A. Ivanov, M. Gromeier, and J. H. Sampson Targeted Therapy for Glioblastoma Multiforme Neoplastic Meningitis with Intrathecal Delivery of an Oncolytic Recombinant Poliovirus Clin. Cancer Res., February 15, 2006; 12(4): 1349 - 1354. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Sloan, J. K. Stewart, A. F. Treloar, R. T. Matthews, and D. G. Jay CD155/PVR Enhances Glioma Cell Dispersal by Regulating Adhesion Signaling and Focal Adhesion Dynamics Cancer Res., December 1, 2005; 65(23): 10930 - 10937. [Abstract] [Full Text] [PDF]
|
|
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||